Table correct to 23/5/22 (Largs Thistle won appeal re: deducted points and total is restored)
West of Scotland Football League Premier Division
| Pos | Club | P | W | D | L | F | A | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Darvel | 38 | 29 | 3 | 6 | 97 | 48 | 49 | 90 |
| 2 | Auchinleck | 38 | 25 | 25 | 4 | 82 | 28 | 54 | 86 |
| 3 | Pollok | 38 | 23 | 7 | 8 | 76 | 37 | 39 | 76 |
| 4 | Clydebank | 38 | 21 | 8 | 9 | 65 | 46 | 19 | 71 |
| 5 | Kilwinning | 38 | 17 | 10 | 11 | 70 | 44 | 26 | 61 |
| 6 | Hurlford Utd | 38 | 17 | 10 | 11 | 56 | 50 | 6 | 61 |
| 7 | Cumnock | 38 | 18 | 3 | 17 | 67 | 58 | 9 | 57 |
| 8 | Irvine Meadow XI | 38 | 17 | 5 | 16 | 55 | 55 | 0 | 56 |
| 9 | Rob Roy | 38 | 17 | 5 | 16 | 63 | 67 | -4 | 56 |
| 10 | Largs Th | 38 | 16 | 7 | 15 | 79 | 60 | 19 | 55 |
| 11 | Beith | 38 | 15 | 9 | 14 | 79 | 61 | 18 | 54 |
| 12 | Glenafton | 38 | 16 | 5 | 17 | 59 | 59 | 0 | 53 |
| 13 | Troon | 38 | 16 | 5 | 17 | 58 | 62 | -4 | 53 |
| 14 | Benburb | 38 | 15 | 7 | 16 | 69 | 62 | 7 | 52 |
| 15 | Glencairn | 38 | 14 | 8 | 16 | 59 | 68 | -9 | 50 |
| 16 | Kilbirnie | 38 | 11 | 7 | 20 | 48 | 70 | -22 | 40 |
| 17 | Cumbernauld | 38 | 10 | 7 | 21 | 47 | 77 | -30 | 37 |
| 18 | Rossvale | 38 | 11 | 4 | 23 | 52 | 92 | -40 | 37 |
| 19 | Blantyre Vics | 38 | 5 | 5 | 28 | 40 | 97 | -57 | 20 |
| 20 | Bonnyton | 38 | 3 | 3 | 32 | 38 | 118 | -80 | 12 |